#dengue #antibody <br> <br>[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Festradiol-e2-antibody%2F[/a] <br> <br>E2 is an estrogen steroid hormone and the primary female sex hormone. <br>It is involved in the regulation of the estrous and menstrual female reproductive cycles. <br>E2 are two types of estrogen, alpha, and beta, which are the most abundant and the most active. Granulosa cells e2 estradiol in ovarian follicles. Its metabolites are estrone and estriol, which have 18 carbons. <br>The target organs are the uterus, vagina, fallopian tube, and pituitary gland. <br>Estrogen prompts cells to make DNA, RNA, and various proteins in their tissues and is involved in regulating the estrous and menstrual female reproductive cycles. <br>                                                                                <br>E2 Products <br>Antibody Application <br>Humanized Anti-human E2 mAb For immunodiagnostic: ELISA, LFA, CLIA <br> <br>E2 Intro <br>E2 is a estradiol antibody. There are two types, α and β, and the α type has a solid physiological effect. Winterstein et al. have been extracted from the urine of pregnant horses and can also be obtained from the urine of pregnant women, human placenta, and pig ovaries. Also present in the testes or urine of male horses. Because it has an intense sex hormone action, it is believed that it or its ester is the essential sex hormone secreted by the ovaries. <br>E2 Testing <br>Estradiol e2 has two types, α, and β. It is a kind of estrogen with the highest content and the most vigorous activity. It is secreted by the granulosa cells of the follicles in the ovary. Its metabolites are estrone and estriol, and it contains 18 carbon atoms. <br>Estrogen can induce cells to synthesize DNA, RNA, and various proteins in corresponding tissues. Its target organs are the uterus, vagina, fallopian tubes, and pituitary gland. It can be used as transdermal estrogen therapy supplements the lack of 17-beta E2 secreted by women&#039;s ovaries while avoiding side effects caused by oral administration (breast pain, weight gain, hypertension, gallstones, abnormal liver function, etc.). <br> <br>As a professional tumor marker factory, SEKBIO has high-quality tumor marker for sale. Welcome to contact us if needed.

#cyfra21 <br>[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fdengue-antibody%2F[/a] <br> <br>Dengue fever is a viral infectious disease that mainly occurs in tropical regions. Spread by Aedes species mosquito, Dengue virus infects millions of people every year. <br>Dengue viruses can divide into 1-4 serotypes based on the antigenicity of viral envelope protein E. Antigenic determinants of viral envelope protein E can induce the production of protective neutralizing antibodies and hemagglutination suppressive antibodies and may be involved in the development of Dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS). <br>SEKBIO developed multiple antigens and antibodies for Dengue ab fever diagnostics, including Dengue NS1 Antibody, Recombinant Dengue Type I NS1 protein, Recombinant Dengue Type II NS1 protein, Recombinant Dengue Type III NS1 protein, Recombinant Dengue Type IV NS1 protein. <br> <br>Dengue Products <br>Antibody Application <br>Dengue NS1 Antibody For immunodiagnostic: ELISA, LFA, CLIA <br> <br>Antigen Application <br>Recombinant Dengue Type I NS1 Protein For immunodiagnostic: ELISA, LFA, CLIA <br>Recombinant Dengue Type II NS1 Protein <br>Recombinant Dengue Type III NS1 Protein <br>Recombinant Dengue Type IV NS1 Protein <br> <br>Dengue Antibody <br>Dengue fever is an acute insect-borne infectious disease caused by the mosquito-borne dengue virus. Dengue virus infection can lead to latent infection, dengue fever, and dengue hemorrhagic fever. The typical clinical manifestations of dengue fever are rapid onset, high fever, headache, severe pain in muscles, bones, joints, skin rash, bleeding tendency, swollen lymph nodes, decreased white blood cell count, and thrombocytopenia in some patients. Dengue hemorrhagic fever is rare in my country. <br>Using ELISA to detect specific IgM antibodies in the serum of patients, positive results are helpful for the early diagnosis of dengue fever. If the dengue virus antigen is caught in the patient&#039;s serum, it can also be used as the basis for a definite diagnosis. <br>Antibody for dengue <br>According to the different antigenicity of viral envelope protein E, the dengue virus is divided into 1 to 4 serotypes. The antigenicity of each type of virus is crossed, but there is no crossover with other antigenic groups of Flaviviridae. The epitope of viral envelope protein E can induce the host to produce protective neutralizing antibodies and hemagglutination-inhibiting antibodies and may be involved in the occurrence of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The nonstructural proteins NS1 and NS3 are both immunoreactive and immunogenic and can induce protective immunity in mice against lethal challenge with homotypic dengue virus. NS1 is a soluble complement-binding antibody with type- and group-specific dengue virus epitopes.

#sekbio <br>[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fcytokeratin-19-fragment-cyfra21-1-tumor-marker%2F[/a] <br> <br>Cytokeratins are epithelial markers whose expression don&#039;t lose during malignant transformation. <br>CYFRA 21–1 is a cytokeratin 19 fragment soluble in serum and can use as a circulating tumour marker. Although expressed in all body tissues, it is significant in the lung, particularly lung cancer tissues. <br>CYFRA 21–1 is a sensitive and specific tumour marker of non-small-cell lung cancer (NSCLC), especially the squamous cell subtype. <br>It also reflects the extent of the disease and has an independent prognostic role along with performance status and disease stage in NSCLC. <br>In addition, detection of serum CYFRA 21 1 allows for identifying high-risk patients that may benefit from adjuvant chemotherapy and enables the early detection of progressive disease in recurrent NSCLC. <br>Additionally, CYFRA 21–1 describe as a valuable marker for oesophagal squamous cell carcinoma and therapy monitoring of bladder cancer. <br> <br>The performance data of the CYFRA21-1 Rapid Quantitative Test Kit (CLIA) <br>Manufacturer SEKBIO <br>Parameter CYFRA21-1 <br>Linearity 0.1-500 ng/ml <br>Detection limit 0.1 ng/ml <br>benchmark product Roche <br>Test principle and procedure CYFRA21-1: Add 10 μl of sample + 30 μl of Ra, incubation for 10 minutes cleaning, 30 μl of Rd incubation for 5 minutes. Wash with 200 μl of washing solution. Finally, add 100 μl of A + 100 μl of B. <br> <br>Six point calibration test results <br>Sample Concentration( ng/ml) <br>RLU Average CV S/N <br>546.75 4,445,546 4,404,255 4,487,587 4,445,796 0.94% 4231.40 <br>93.62 706,516 710,963 736,349 717,943 2.24% 683.32 <br>9.57 69,190 68,756 68,034 68,660 0.85% 65.35 <br>1.03 7,703 7,728 7,799 7,743 0.64% 7.37 <br>0.11 1,703 1,727 1,553 1,661 5.68% 1.58 <br>0.01 1,181 1,003 968 1,051 10.87% 1.00  <br> <br>Precision <br>Sample RLU Concentration Sample RLU Concentration <br> <br> <br> <br> <br> <br>1 6,482 0.76 <br> <br> <br> <br> <br>75 552,944 72.72 <br> 5,679 0.72 564,704 74.21 <br> 6,317 0.80 563,241 74.03 <br> 5,976 0.77 558,522 73.43 <br> 6,211 0.82 570,900 75.00 <br> 5,873 0.81 566,827 74.48 <br> 6,055 0.79 545,138 71.72 <br> 6,028 0.79 573,240 75.30 <br> 5,927 0.82 550,118 72.36 <br> 6,166 0.84 555,993 73.10 <br>AVE 6,71.40 0.79 AVE 560,162.70 73.63 <br>SD 231.61 0.03 SD 9187.21 1.17 <br>CV 3.8% 4.3% CV 1.6% 1.6% <br> <br>Limit of detection <br>Sample RLU Concentration <br> <br> <br> <br> <br>Ag Diluent 1,108 1,164 0.025 0.016 <br> 1,124 1,128 0.019 0.019 <br> 1,024 1,037 0.003 0.001 <br> 1,103 1,103 0.015 0.015 <br> 1,055 1,090 0.013 0.007 <br> 1,118 1,043 0.004 0.018 <br> 1,094 1,183 0.029 0.013 <br> 1,040 1,082 0.011 0.004 <br> 947 918 0 0 <br> 1,054 1,110 0.016 0.006 <br>AVE 1,076.25 0.01 <br>SD 64.60 0.01 <br>AVE+2*SD 0.028 <br> <br>Linear <br>Sample（ng/ml) Dilution ratio Concentration value Average <br>438.24 1.0 448.87 443.83 422.03 438.24 <br>350.61 0.8 337.81 349.19 342.22 343.07 <br>262.98 0.6 243.27 247.31 232.15 240.91 <br>175.35 0.4 148.61 151.02 151.09 150.24 <br>87.72 0.2 72.49 69.26 69.64 70.46 <br>0.09 0.0 0.08 0.10 0.09 0.09  <br>Method Comparison <br>Reagents Stability <br>Reagent Sample(ng/ml) Average Deviation <br>2-8℃ 70.00 2,862,814 <br> 10.00 424,472 <br> 0.10 9,674 <br> Antigen diluent 4,025 <br> random sample 21,808 <br> calf serum 4,816 <br>37℃ 1d 70.00 2,717,873 -5.06% <br> 10.00 415,759 -2.05% <br> 0.10 9,322 -3.64% <br> Antigen diluent 4,062 0.91% <br> random sample 21,842 0.16% <br> calf serum 4,626 -3.96% <br>37℃ 3d 70.00 2,720,985 -4.95% <br> 10.00 434,677 2.40% <br> 0.10 9,822 1.52% <br> Antigen diluent 4,339 7.80% <br> random sample 22,399 2.71% <br> calf serum 4,965 3.09% <br>37℃ 7d 70.00 2,683,682 -6.26% <br> 10.00 408,162 -3.84% <br> 0.10 9,285 -4.02% <br> Antigen diluent 4,224 4.93% <br> random sample 23,879 9.49% <br> calf serum 5,120 6.31% <br> <br>Cytokeratin 19 Fragment (CYFRA21-1) Products <br>Name Application <br>Mouse anti-human CYFRA21-1 mAb For immunodiagnostic: ELISA, LFA, CLIA <br>Humanized anti-human CYFRA21-1 mAb <br> <br>CYFRA21-1 Intro <br>In malignant epithelial cells, the activated protease accelerates the degradation of the cells so that a large number of cytokeratin fragments are released into the blood, and the soluble pieces can specifically bind to the two monoclonal antibodies KS19.1 and BM19.21, so it is called CYFRA21 -1. In malignant lung cancer tissues, CYFRA21-1 is abundant, especially in lung squamous cell carcinoma. The molecular weight of CYFRA21-1 is about 30,000 Da. <br> <br>The serum level of CYFRA21-1 was not related to age, gender, smoking, and pregnancy. Pneumonia, tuberculosis, bronchitis, bronchial asthma, emphysema, and other diseases generally do not cause CYFRA21-1 elevation. Benign liver disease renal failure can cause a slight increase, but rarely more than 10ng/ml. <br> <br>Cytokeratin Tumor Marker <br>Cytokeratin (CK) classifies intermediate filaments that constitute the cytoskeleton. There are many types, among which the cytokeratin 19 (CK19) fragment CYFRA21-1 is the most important in the diagnosis of malignant tumors; the release of CK19 increases when cells become cancerous. , After CK19 is degraded by protease or apoptosis, its fragments are released into the blood. The expression of different keratin fragments has the specificity of tissue distribution, squamous cell carcinoma and adenocarcinoma mainly express CK19, small cell undifferentiated carcinoma mainly express CK18 or only a tiny amount of CK19. CYFRA21-1 is a fragment of cytokeratin 19. It is composed of two monoclonal antibodies to cytokeratin 19, the main component of the cell structure. It is mainly found in the cytoplasm of tumor cells of epithelial origin, such as lung cancer and esophageal cancer. All lung squamous cell carcinomas express CYFRA21-1. When the cells become cancerous, the release of CYFRA21-1 due to the necrolysis of tumor cells increases the blood content, reflecting the prognosis and therapeutic efficacy of the disease. Since the serum product of CK19, CYFRA21-1, is a non-organ-specific tumor marker, comprehensive analysis of clinical data should be combined in clinical application to make a more accurate judgment. <br> <br>As a professional tumor marker factory, SEKBIO has high-quality tumor marker for sale. Welcome to contact us if needed.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fcreatine-kinase-mb-ckmb%2F[/a] <br> <br>#CK #MB #protein <br> <br>Creatine kinase isoenzymes are an enzyme component, among which MB type is mainly present in myocardial cells. It is also a kind of cardiac marker. <br> <br>CK MB protein is of great significance in clinical diagnosis. The serum creatine kinase level increases rapidly in various diseases, including muscular atrophy and myocardial infarction. The determination of creatine kinase activity is more reliable than electrocardiogram in the diagnosis of myocardial infarction. In myocardial infarction, creatine kinase increased within six h of onset, peaked at 24 h, and returned to normal within 3-4 days. <br> <br>The isoenzyme CK-MB of creatine kinase has the highest specificity in diagnosis. Creatine kinase has attracted extensive attention and in-depth research because of its essential physiological function and clinical application value. <br> <br>SEKBIO provides related detection raw materials: Mouse anti-human CKMB mAb and Humanized anti-human CKMB mAb.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fc-reaction-protein-crp-inflammatory-marker%2F[/a] <br> <br>#CRP #marker <br> <br>C-reactive protein (CRP) refers to several proteins (acute proteins) that rise sharply in blood plasma in response to infection or tissue damage. <br> <br>CRP marker can activate complement and strengthen the phagocytosis of phagocytes and play an optimizing role, thus removing pathogenic microorganisms and damaged, necrotic, and apoptotic tissue cells from the body and playing an essential protective role in the natural immune process of the body. <br> <br>C-reactive protein is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. <br>A CRP test measures the amount of CRP in the blood plasma samples to detect inflammation due to acute conditions or to monitor disease severity in chronic conditions. <br> <br>CRP Intro <br>C-reactive protein (CRP) refers to some proteins (acute proteins) that rise sharply in plasma when the body is infected or tissue damaged. CRP can activate complement and strengthen the phagocytosis of phagocytes to play an opsonizing effect, thereby removing pathogenic microorganisms and damaged, necrotic, and apoptotic tissue cells that invade the body and play an important protective role in the body&#039;s natural immune process.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fcardiac-troponin-i-ctni%2F[/a] <br> <br>#SEKBIO <br> <br>Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. Cardiac troponin I protein consists of 209 amino acid residues. The theoretical pI of cTnI is 9.05. cTnI is more sensitive and specific in diagnosing myocardial infarction. <br> <br>Phosphorylation of ctni antibody changes the conformation of the protein and modifies its interaction with other troponins and the interaction with anti-TnI antibodies. These changes alter the myofilament response to calcium and are of interest in targeting heart failure. Multiple reaction monitoring of human cTnI has revealed 14 phosphorylation sites, and the pattern of phosphorylation observed in these sites changed in response to disease. <br> <br>Measuring cardiac biomarkers can be a step toward making a diagnosis for a condition. Whereas cardiac imaging often confirms a diagnosis, more straightforward and less expensive cardiac markers test can advise a physician whether more complicated or invasive procedures are warranted. In many cases, medical societies recommend doctors to make biomarker measurements an initial testing strategy, especially for patients at low risk of cardiac death.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fca50-tumor-marker%2F[/a] <br> <br>#ca #50 #tumor #marker <br> <br>CA50 is a kind of sialic acid ester and sialic acid glycoprotein, which generally does not exist in normal tissues. When cells become malignant, glycosylation enzyme is activated, resulting in changes of glycosylation structure on the cell surface and becoming A MARKER of CA50. <br> <br>The ca 50 tumor marker is a chemical that reflects the presence of a tumour. <br>Cancer antigen CA50 does not exist in normal adult tissues, which restricted to embryonic tissues, or in the tissue of cancer than in normal tissue, their existence or quantitative change may indicate the nature of the tumour to understand the tumour tissue, cell differentiation and cell function, to help the diagnosis, classification and prognosis judgement and treatment of tumour. <br> <br>CA 50 Marker Intro <br>CA50 is a chemical class that reflects the presence of tumors. They do not exist in normal adult tissues but only in embryonic tissues, or the content in tumor tissues dramatically exceeds that in normal tissues. Their presence or quantitative changes can indicate the nature of tumors to understand tumor histogenesis, cell differentiation, and cell function to help tumor diagnosis, classification, prognosis, and treatment guidance.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fca242-tumor-marker%2F[/a] <br> <br>#SEKBIO <br> <br>CA242, or Cancer Antigen 242, is a notable glycoprotein biomarker within the realm of oncology and the biomedical industry. It is classified as a mucin, a type of glycoprotein characterized by extensive glycosylation and an often elongated structure. CA242 is composed of a unique amino acid sequence, primarily consisting of tandem repeats rich in proline, threonine, and serine residues. These repeats contribute to its mucinous and glycosylated nature, facilitating its distinctive role in various types of cancer. <br>  <br>The amino acid sequence of CA242, which varies slightly between individuals, comprises a central core protein with extensive glycosylation sites. The glycosylation of CA242 involves the addition of carbohydrate molecules, particularly O-linked glycans, enhancing its stability and modulating its functions. The specific amino acid sequence and glycosylation pattern are critical factors in the structural integrity and functionality of CA242, making it an important target for detection and analysis in cancer diagnostics. <br> 

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fca19-9-tumor-marker%2F[/a] <br> <br>#SEKBIO <br> <br>CA19-9 Tumor Marker <br>Cancer antigen 19-9 (CA199 Marker )refers to a tumor marker associated with pancreatic, gallbladder, colon, and stomach cancers and is also known as an associated gastrointestinal antigen.  <br>Cancer antigen 19-9 has high sensitivity and specificity for pancreatic cancer. Detection of ca199 tumor marker is helpful for differential diagnosis, disease monitoring, and diagnosis of pancreatic cancer metastasis. <br> <br>SEKBIO is now offering Mouse anti-human CA19-9 mAb and Humanized anti-human CA19-9 mAb. These antibodies are suitable for use in diagnostics, including ELISA, lateral flow, CLIA, etc. And our products are highly consistent with Roche kits and similar antibodies of CanAg. <br> <br>Tumor Marker CA19-9 Antigen <br>Cancer antigen 199(CA19-9 Tumor Marker ) refers to a tumor marker associated with pancreatic cancer, gallbladder cancer, colon cancer, and gastric cancer, also known as a gastrointestinal tract-associated antigen. tumor marker ca199 has high sensitivity and specificity for pancreatic cancer, and its positive rate is between 85% and 95%, and it decreases with the improvement of the condition after surgery.

[a]https%3A%2F%2Fwww.sekbio.com%2Fproducts%2Fblood-test-inflammatory-marker%2F[/a] <br> <br>#SEKBIO <br> <br>Inflammatory cytokines refer to various cytokines involved in the inflammatory response. And the inflammatory markers can identify the severity and fatality of the disease.  <br>Procalcitonin (PCT), serum ferritin, C-reactive protein (CRP), and interleukin-6 (IL-6) are significantly associated with the high risks of the development of severe disease. And Serum amyloid A (SAA) can serve as a biomarker for monitoring disease progression. <br>SEKBIO is now offering antibodies, antigens, and CLIA bulk reagents for these test items. These products&#039; performance has been evaluated based on the CLIA method, head-to-head comparison with Roche ECLIA product, and the consistency shows excellent consistency. <br> <br>Inflammatory Marker Intro <br>Inflammation marker refer to the indicators on which inflammatory diseases are judged in clinical diagnosis. When bacteria (or viruses) infect biological organisms, the body often has an inflammatory response, manifested as fever, increased white blood cell count, accelerated erythrocyte sedimentation rate (erythrocyte sedimentation rate), and increased various acute-phase proteins.