EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2.

Color-dyes polystyrene particles conjugated with recognition molecules as antibodies, antigens, proteins, or other biomacromolecules are available on request. Unmodified polymer spheres are also offered. These polymer particles find extensive applications in a range of flow assays, diagnostic tests, optical and electronic instrument testing, and calibration.

CD Bioparticles provide a wide range of uniform and monodisperse colored polystyrene particles. Our colored particles are prepared by polymerizing styrene in oil soluble dye solution in styrene. Therefore, the particles do not contain the solvents commonly found in the preparation of particles by staining with dye solutions in organic solvents. Diagpoly™ Colored Polystyrene Particles are intensely colored, which can enhance the visual detection in assays such as latex agglutination, dipstick, and membrane-based assays.

MIL-101 (Cr) <br> <br>Catalog: CDM-CH230

NH-Bis(PEG3-acid) HCl salt is a branched PEG derivative with a central amino group and two terminal carboxylic acids. The amino group is reactive with carboxylic acids, activated NHS ester, carbonyls, etc. The terminal carboxylic acids can be reacted with primary amino groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Vinylsulfone-PEG-vinylsulfone (VS-PEG-VS) is a thiol reactive homobifunctional PEG for sulfhydryl pegylation at high pH. Homobifunctional PEG derivatives have numerous applications as crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs ensures an increased drug load compared to pegylation with linear PEGs.

Absolute Mag™ DNA Magnetic Particles, Silica-coated, 1.0 μm (#WHM-G180) are superparamagnetic particles with porous silica coating. These particles are designed for automatic DNA/RNA separation such as genomic DNA, plasmid DNA, total RNA and PCR products. DNA/RNA bind to these porous silica surface under high salts conditions (5 M guanidinium thiocyanate).

Basic magnetic particles can be further coated and functionalized for biotechnology and biomedical applications. In vitro, magnetic beads are widely used in diagnostic and separation of biomolecules, such as protein, cell, DNA/RNA, microorganism. In vivo, magnetic beads have been used both in therapeutic (drug delivery and hyperthermia) and diagnostic applications (magnetic resonance imaging(MRI)).

CD Bioparticles offers unmodified magnetic particles to meet our customers’multiple needs. The magnetic functionality of magnetic particles is determined by composition, size, and shape of its magnetic core. These cores can be made from different materials and with varying sizes, shapes, uniformities, and magnetic properties. Our scientists are experts in preparing magnetic particles in various forms, including pureiron and cobalt metals, alloys such as CoPt3, FePt,FeZn, iron oxides which includes magnetite (Fe3O4) and maghemite (γ-Fe2O3). We also dope iron oxides with Mn, Fe, Co or Nito form MFe2O4 structures and enhance their magnetic properties.

Fluorescent leakage assay is a method that is extensively used for measuring the disruption of the liposomal membrane due to various external triggers such as interaction of molecules (e.g. peptides, proteins, detergents and etc.) with the surface of the liposomes. Liposomal membrane can also be disrupted when external energy is given to the system such as exposure of liposomes to sonic sound, mechanical pressure or heat. When liposomes are disrupted, their content will leak out of the liposomes. If you investigate the old literature, you will realize that in a large percentage of fluorescent leakage assay, the experiments involves encapsulating a self quenching concentration of fluorescent dyes such as calcein and carboxyfluorescein. The problem with calcein and carboxyfluorescein is that the liposomes have to be made very fresh and be used right away. These molecules have a tendency to leak out quickly in the absence of any trigger especially when unsaturated lipids are used. This will cause the assay to be less sensitive and the data not to be reproducible.

Stearate-modified methyl cellulose

Can be used as monomers to synthesize COF materials