The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 500 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.

Description: <br> <br>Pilot Scale High Pressure Homogenizer with Dual Pump for continuous pressure up to 45,000 psi <br> <br>Application: <br> <br>Nanodispersions, nanoemulsions and nanotube, graphene, <br>Cell disruption, <br>Micro/nanoencapsulation in polymers, liposomes and oils, <br>Solid dispersion and suspension, deagglomeration <br> <br>Performance: <br> <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions) <br>Silent (noiseless performance with high energy efficiency) <br>Strong (more than 30L/hr at 30,000 psi) <br>CE compliant and RoHS compliant

Manufacturing Scale High Pressure Homogenizer with Dual or Quad Pumps, designed to provide constant pressure up to 45,000 psi to the product stream. This, in turn, results in less processing time and maximizes the microfluidics homogenizing performance. The ManuGenizer utilizes a microfluidics Diamond Interaction Chamber with multi-slotted nano-size micro channels inside the chamber, which allows for much larger volumes to be continuously processed. <br> <br>Application: <br> <br>Nanodispersions, nanoemulsions and nanotube, graphene, <br>Cell disruption, <br>Micro/nanoencapsulation in polymers, liposomes and oils, <br>Solid dispersion and suspension, deagglomeration <br> <br>Performance: <br> <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions) <br>Silent (noiseless performance with high energy efficiency) <br>Strong (up to 480L/hr at 30,000 psi, water value) <br>CE compliant and RoHs compliant

Description: <br> <br>A homogenizer designed especially for mixing and homogenizing the sample fluids from two or more inlet ports. <br> <br>Application: <br> <br>Nanodispersions, nanoemulsions and nanotube <br>Cell disruption <br>Micro/nanoencapsulation in polymers, liposomes and oils <br>Solid dispersion and suspension, deagglomeration <br> <br>Performance: <br> <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume) <br>Silent (noiseless performance) <br>Strong (more than 100 mL/min at 30,000 psi) <br>CE compliant and RoHS compliant

Description: <br>Portable laboratory testing up to 45,000 psi with electric power. <br> <br>Application: <br>Nanodispersions, nanoemulsions and nanotube <br>Cell disruption <br>Micro/nanoencapsulation in polymers, liposomes and oils <br>Solid dispersion and suspension, deagglomeration <br> <br>Performance: <br>Energy-efficient, only 1/2 energy loss of most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems provide precise functions: controlled inlet volume ± 0.1mL; auto stop with time/volume) <br>Silent (noiseless performance with high energy efficiency) <br>Strong (more than 150mL/min at 30,000 psi) <br>CE compliant and RoHS compliant

Description: <br> Quad-Pump Laboratory-Scale High Pressure Homogenizers <br> <br>Laboratory Quad-Pump up to 30,000 psi with concept testing of parallel and series flow direction. <br> <br>Application: <br>Nanodispersions, nanoemulsions and nanotube <br>Cell disruption <br>Micro/nanoencapsulation in polymers, liposomes and oils <br>Solid dispersion and suspension, deagglomeration <br> <br>Performance: <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions: auto stop with time/volume) <br>Silent (noiseless performance) <br>Strong (6-27L/hr) <br>CE compliant and RoHs compliant <br> <br>Specification <br>Catalog No. NanoGenizer-Quad <br>Flow Rate 6-27L/hr <br>Min. Sample 5mL <br>Max. Pressure 30,000psi <br>Dimensions(cm) 92 × 69 × 40 <br>Weight 117 kg (258 lbs) <br>Max. Temp. 80ºC (176ºF) <br>Power 220V <br>Cleaning Flush to clean <br>Application Nano emulsion, fat emulsion, liposome, cell disruption, nano dispersion, deagglomeration <br>Features Digital display of pressure or pressure gauge <br> <br>Standard Features <br>Parts Y-type diamond interaction chamber with cooling option <br>Control System High pressure programming control systems: touch screen, speed control, auto stop control by volume, time, pressure or temperature, display of flow rate and time, overload protection <br>Pressure Gauge Digital display on the touch screen <br>Inlet Type Tri-clamp <br>Outlet Type Tri-clamp <br>Inlet Reservoir 500mL S/S cylinder <br>Outlet Reservoir Plastic hose <br>Product Material 316L stainless steel, tungsten carbide, viton, teflon <br>Material Standard Sanitary grade, FDA, GMP <br>Warranty 1 year against any manufacturing defects

Z-Type Diamond Interaction Chamber (DIXC) is used to produce uniform nanoparticles in a high-pressure homogenizer. The fixed geometry within the Z-Type DIXC is intended to create a uniform processing profile so that all materials will be processed with equal disruptive forces. Single-slotted interaction chambers have a single microchannel and are ideal choices for small batch research, while the multi-slotted interaction chamber comprises multiple microchannels in parallel, which can be used at industrial scales, by increasing the flow rate through the DIXC but with equal processing forces. <br> <br>Application: <br>Nanoemulsion, cell disruption, nanodispersion, deagglomeration, liposome <br> <br>Performance: <br>Full replacement for the chamber of Microfluidizer processors <br>Electro-polishing and inner passivation for pharmaceutical applications <br>Real-time cooling option to reduce oversized particles <br>Lower cost and higher quality

UltraGenizer High Shear Homogenizer: <br>UltraGenizer is a laboratory ultra high pressure processing device. It is an electrically-driven and bench-top high shear homogenizer, which requires no compressed air or hydraulic oil to achieve maximum 4,200 bar (60,000 psi) operating pressure. <br> <br>Application of UltraGenizer High Shear Homogenizer: <br>Nano emulsions <br>Nano dispersions <br>Liposomes <br>Nanoparticles <br>Graphene <br>Deagglomeration <br> <br>Performance of UltraGenizer High Shear Homogenizer: <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume) <br>Silent (noiseless performance) <br>Strong (more than 150 mL/min at 60,000 psi) <br>CE compliant and RoHS compliant

NanoGenizer High Pressure Homogenizer: <br>NanoGenizer is a laboratory high pressure processing device. It is an electrically-driven and bench-top, high pressure homogenizer requiring no compressed air or hydraulic oil to achieve maximum 3,062 bar (45,000 psi) operating pressure. <br> <br>NanoGenizer high pressure homogenizer is composed of a feed reservoir, high pressure pump, transducer, PLC control panel and microfluidics diamond interaction chamber. The sanitary pump system of the NanoGenizer high pressure homogenizer is able to supply the desired pressure to the product stream and push it through the micron chamber (microreactor) to create high shear rates and strong impact within the stream. This process results in uniform particle distribution and smaller particle sizes. <br> <br>Application of NanoGenizer High Pressure Homogenizer: <br>Cell disruption and particle size reduction <br>Nanoemulsions <br>Nano dispersions <br>Liposomes <br>Deagglomeration <br> <br>Performance of NanoGenizer High Pressure Homogenizer: <br>Energy efficient, 1/2 energy loss of the most homogenizers <br>Small (integrated design delivers the light weight and small dimensions) <br>Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume) <br>Silent (noiseless performance) <br>Strong (more than 150 mL/min at 30,000 psi) <br>CE compliant and RoHs compliant

NanoGenizer High Pressure Homogenizer: <br>NanoGenizer is a laboratory high pressure processing device. It is an electrically-driven and bench-top, high pressure homogenizer requiring no compressed air or hydraulic oil to achieve maximum 3,062 bar (45,000 psi) operating pressure. <br> <br>NanoGenizer high pressure homogenizer is composed of a feed reservoir, high pressure pump, transducer, PLC control panel and microfluidics diamond interaction chamber. The sanitary pump system of the NanoGenizer high pressure homogenizer is able to supply the desired pressure to the product stream and push it through the micron chamber (microreactor) to create high shear rates and strong impact within the stream. This process results in uniform particle distribution and smaller particle sizes. <br> <br>Application of NanoGenizer High Pressure Homogenizer: <br>Cell disruption and particle size reduction <br>Nanoemulsions <br>Nano dispersions <br>Liposomes <br>Deagglomeration

Description: <br>Genizer Online Liposome Extruders can be connected with a sanitary pump or high pressure homogenizer and are temperature controlled, from testing to manufacturing production of pharmaceuical liposomes for anti-cancer drugs. Homogenous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Online Liposome Extruders are designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Online Liposome Extruder offers virtually no dead volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals. <br> <br>Application: <br>Liposome extrusion; Sterile filtration <br> <br>Performance: <br>No dead volume <br>Online extruder can control the temperature of extrusion

The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogenous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 3,000 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals. <br> <br>Application: <br>Liposome extrusion <br> <br>Performance: <br>No dead volume <br>The Jacketed Extruder can control the temperature of the extrusion